Modulation of intestinal epithelial cell proliferation and apoptosis by Lactobacillus gasseri SF1183.

ABSTRACT: The gut microbiota exerts a variety of positive effects on the intestinal homeostasis, including the production of beneficial molecules, control of the epithelial barrier integrity and the regulation of the balance between host's cell death and proliferation. The interactions between commensal bacteria and intestinal cells are still under-investigated and is then of paramount importance to address such interactions at the molecular and cellular levels. We report an in vitro analysis of the effects of molecules secreted by Lactobacillus gasseri SF1183 on HCT116 cells, selected as a model of intestinal epithelial cells. SF1183 is a L. gasseri strain isolated from an ileal biopsy of a human healthy volunteer, able to prevent colitis symptoms in vivo. Expanding previous findings, we show that

SUBMITTER: Di Luccia B 

PROVIDER: S-EPMC9691729 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature