Per1 gene polymorphisms influence the relationship between brain white matter microstructure and depression risk.

ABSTRACT:

Background

Circadian rhythm was involved in the pathogenesis of depression. The detection of circadian genes and white matter (WM) integrity achieved increasing focus for early prediction and diagnosis of major depressive disorder (MDD). This study aimed to explore the effects of PER1 gene polymorphisms (rs7221412), one of the key circadian genes, on the association between depressive level and WM microstructural integrity.

Materials and methods

Diffusion tensor imaging scanning and depression assessment (Beck Depression Inventory, BDI) were performed in 77 healthy college students. Participants also underwent PER1 polymorphism detection and were divided into the AG group and AA group. The effects of PER1 genotypes on the association between the WM characteristics and BDI we

SUBMITTER: Zhao R 

PROVIDER: S-EPMC9691780 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature