Sex-specific brain microstructural reorganization in irritable bowel syndrome.

ABSTRACT:

Abstract

Preliminary evidence suggests that there are sex differences in microstructural brain organization among individuals with irritable bowel syndrome (IBS). The aim of this study was to further investigate sex-dependent differences in brain microstructure and organization in a large sample of well-phenotyped participants with IBS compared with healthy controls. We hypothesized that female patients with IBS would show evidence for increased axonal strength and myelination within and between brain regions concerned with pain and sensory processing, when compared with males with IBS. We also hypothesized that female compared with male IBS subjects show greater levels of somatic awareness and sensory sensitivity consistent with multisystem sensory sensitivity. Diffusion tensor im

SUBMITTER: Labus JS 

PROVIDER: S-EPMC9691795 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature