A prospective multicenter study on varicella-zoster virus infection in children with acute lymphoblastic leukemia.

ABSTRACT:

Background and methods

The study evaluated prognostic factors associated with varicella-zoster virus (VZV) infection and mortality in children with acute lymphoblastic leukemia (ALL) using data from the multicenter Chinese Children's Cancer Group ALL-2015 trial.

Results

In total, 7,640 patients were recruited, and 138 cases of VZV infection were identified. The incidence of VZV infection was higher in patients aged ≥ 10 years (22.5%) and in patients with the E2A/PBX1 fusion gene (11.6%) compared to those aged < 10 years (13.25%, P = 0.003) or with other fusion genes (4.9%, P = 0.001). Of the 10 deaths in children with ALL and VZV infection, 4 resulted from VZV complications. The differences between groups in the 5-year overall survival, event-free surviv

SUBMITTER: Xiao P 

PROVIDER: S-EPMC9691833 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature