A ferroptosis-related gene signature associated with immune landscape and therapeutic response in osteosarcoma.

ABSTRACT:

Background

The role of ferroptosis in tumor progression and immune microenvironment is extensively investigated. However, the potential value of ferroptosis regulators in predicting prognosis and therapeutic strategies for osteosarcoma (OS) patients remains to be elucidated.

Methods

Here, we extracted transcriptomic and survival data from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) to investigate the expression and prognostic value of ferroptosis regulators in OS patients. After comprehensive analyses, including Gene set variation analysis (GSVA), single-sample gene-set enrichment analysis (ssGSEA), Estimated Stromal and Immune cells in Malignant Tumor tissues using Expression (ESTIMATE), single-cell RNA seq

SUBMITTER: Wang X 

PROVIDER: S-EPMC9691858 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature