Systemic polidocanol from intravenous or pressurized intrauterine administration produces reversible cardiovascular toxicity.

ABSTRACT:

Objective

Fatal allergic responses and cardiac arrhythmias have been reported with the intravenous (IV) administration of polidocanol. We sought to identify the physiologic mechanism of systemic cardiovascular response after transcervical (TC) and IV administration of polidocanol.

Methods

We continuously monitored blood pressure (BP) and heart rate using an arterial line during IV and intraperitoneal (IP) administration of polidocanol solution (PS) and polidocanol doxycycline solution in female rats and TC and IP administration of polidocanol foam (PF) and PDF (TC only) in female baboons. We performed TC procedures using a catheter with (pressurized) and without (nonpressurized) balloon inflation. Baboons also underwent monitoring during IV PS administration with and without

SUBMITTER: Jensen JT 

PROVIDER: S-EPMC9692028 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature