Wingless-related integration site (WNT) signaling is activated during the inflammatory response upon cardiac surgery: A translational study.

ABSTRACT:

Objective

Cardiac surgery and the use of cardiopulmonary bypass initiate a systemic inflammatory response. Wingless-related integration site (WNT) signaling is part of the innate immunity and has been attributed a major role in the regulation of inflammation. In preclinical research, WNT-5a may sustain an inflammatory response and cause endothelial dysfunction. Our aim was to investigate WNT signaling after cardiac surgery and its association with postoperative inflammation (Clinicaltrials.gov, NCT04058496).

Methods

In this prospective, single-center, observational study, 64 consecutive patients for coronary artery bypass grafting (CABG) ± valve surgery were assigned into three groups: off-pump CABG (n = 28), on-pump CABG (n = 16) and combined valve-CABG surger

SUBMITTER: Kruger BD 

PROVIDER: S-EPMC9692086 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature