The impact of Traditional Chinese Medicine on mouse gut microbiota abundances and interactions based on Granger causality and pathway analysis.

ABSTRACT:

Objectives

The intestinal microbiota is essential in absorbing nutrients and defending against pathogens and is associated with various diseases, including obesity, type 2 diabetes, and hypertension. As an alternative medicine, Traditional Chinese Medicine (TCM) has long been used in disease treatment and healthcare, partly because it may mediate gut microbiota. However, the specific effects of TCM on the abundance and interactions of microbiota remain unknown. Moreover, using TCM ingredients and data detailing changes in the abundance of gut microorganisms, we developed bioinformatic methods that decipher the impact of TCM on microorganism interactions.

Methods

The dynamics of gut microorganisms affected by TCM treatments is explored using a mouse model, which provided the

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9692106 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature