Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts.
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ABSTRACT:
SUBMITTER: Prince N
PROVIDER: S-EPMC9692427 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts.
Prince Nicole N Kim Min M Kelly Rachel S RS Diray-Arce Joann J Bønnelykke Klaus K Chawes Bo L BL Huang Mengna M Levy Ofer O Litonjua Augusto A AA Stokholm Jakob J Wheelock Craig E CE Bisgaard Hans H Weiss Scott T ST Lasky-Su Jessica A JA
Metabolites 20221113 11
Recurrent respiratory infections are a leading cause of morbidity and mortality in early life, but there is no broadly accepted means to identify infection-prone children during this highly vulnerable period. In this study, we investigated associations between steroid metabolites and incident respiratory infections in two pre-birth cohorts to identify novel metabolomic signatures of early infection proneness. Children from the Vitamin D Antenatal Asthma Reduction Trial and the Copenhagen Prospec ...[more]
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