Phylogenomic and Evolutionary Analyses Reveal Diversifications of SET-Domain Proteins in Fungi.

ABSTRACT: In recent years, many publications have established histone lysine methylation as a central epigenetic modification in the regulation of chromatin and transcription. The histone lysine methyltransferases contain a conserved SET domain and are widely distributed in various organisms. However, a comprehensive study on the origin and diversification of the SET-domain-containing genes in fungi has not been conducted. In this study, a total of 3816 SET-domain-containing genes, which were identified and characterized using HmmSearch from 229 whole genomes sequenced fungal species, were used to ascertain their evolution and diversification in fungi. Using the CLANS program, all the SET-domain-containing genes were grouped into three main clusters, and each cluster contains several groups. Domain

SUBMITTER: Ding G 

PROVIDER: S-EPMC9692433 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature