Stress Responses Elicited by Glucose Withdrawal in Aspergillus fumigatus.

ABSTRACT: Glucose is a widely used carbon source in laboratory practice to culture Aspergillus fumigatus, however, glucose availability is often low in its "natural habitats", including the human body. We used a physiological-transcriptomical approach to reveal differences between A. fumigatus Af293 cultures incubated on glucose, glucose and peptone, peptone (carbon limitation), or without any carbon source (carbon starvation). Autolytic cell wall degradation was upregulated by both carbon starvation and limitation. The importance of autolytic cell wall degradation in the adaptation to carbon stress was also highlighted by approximately 12.4% of the A. fumigatus genomes harboring duplication of genes involved in N-acetyl glucosamine utilization. Glucose withdrawal incre

SUBMITTER: Emri T 

PROVIDER: S-EPMC9692504 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature