Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules.

ABSTRACT: Protozoan parasites are responsible for several harmful and widespread human diseases that cause high morbidity and mortality. Currently available treatments have serious limitations due to poor efficiency, strong adverse effects, and high cost. Hence, the identification of new targets and the development of specific drug therapies against parasitic diseases are urgent needs. Heat shock protein 90 (HSP90) is an ATP-dependent molecular chaperone that plays a key role in parasite survival during the various differentiation stages, spread over the vector insect and the human host, which they undergo during their life cycle. The N-terminal domain (NTD) of HSP90, containing the main determinants for ATPase activity, represents the most druggable domain for inhibitor targeting. The molecules inv

SUBMITTER: Tassone G 

PROVIDER: S-EPMC9692773 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature