Synthesis & Evaluation of Novel Mannosylated Neoglycolipids for Liposomal Delivery System Applications.

ABSTRACT: Glycosylated NPs, including liposomes, are known to target various receptors involved in cellular carbohydrate transport, of which the mannoside binding receptors are attracting particular attention for their expression on various immune cells, cancers, and cells involved in maintaining central nervous system (CNS) integrity. As part of our interest in NP drug delivery, mannosylated glycoliposomal delivery systems formed from the self-assembly of amphiphilic neoglycolipids were developed, with a C₁₂-alkyl mannopyranoside (ML-C₁₂) being identified as a lead compoundcapable of entrapping, protecting, and improving the delivery of structurally diverse payloads. However, ML-C₁₂ was not without limitations in both the synthesis of the glycolipids, and the physic

SUBMITTER: Mousavifar L 

PROVIDER: S-EPMC9692915 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature