Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia.

ABSTRACT: Pneumonia is a common cause of morbidity and mortality and is most often caused by bacterial pathogens. COVID-19 is characterized by lung infection with potential progressive organ failure. The systemic consequences of both disease on the systemic blood metabolome are not fully understood. The aim of this study was to compare the blood metabolome of both diseases and we hypothesize that plasma metabolomics may help to identify the systemic effects of these diseases. Therefore, we profiled the plasma metabolome of 43 cases of COVID-19 pneumonia, 23 cases of non-COVID-19 pneumonia, and 26 controls using a non-targeted approach. Metabolic alterations differentiating the three groups were detected, with specific metabolic changes distinguishing the two types of pneumonia groups. A comparison o

SUBMITTER: More TH 

PROVIDER: S-EPMC9693035 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature