ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin.

ABSTRACT: The use of nanomaterials for the controlled release of drugs aims to enhance their effectiveness, especially when poorly soluble in water, and achieve their rapid, localized, and effective administration. The present study focuses on the use of a Zeolitic Imidazolate Framework-8 (ZIF-8) as vehicle for the transport and controlled release of the antibiotic ciprofloxacin (CIP) as model due to its favorable physicochemical characteristics. The objective is to synthesize the ZIF-8 material loaded with CIP through encapsulation for subsequent release of the drug in neutral and acid physiological media. In addition, functionalization of the CIP/ZIF compound with magnetic nanoparticles (NP) was sought to increase its traceability through the possible use of magnetic fields. Characterizations by X

SUBMITTER: Ramos VC 

PROVIDER: S-EPMC9693427 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature