Effect of Pd₂Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics.

ABSTRACT: Cisplatin (cDDP)-based chemotherapy is often limited by severe deleterious effects (nephrotoxicity, hepatotoxicity and neurotoxicity). The polynuclear palladium(II) compound Pd₂Spermine (Pd₂Spm) has emerged as a potential alternative drug, with favorable pharmacokinetic/pharmacodynamic properties. This paper reports on a Nuclear Magnetic Resonance metabolomics study to (i) characterize the response of mice brain and liver to Pd₂Spm, compared to cDDP, and (ii) correlate brain-liver metabolic variations. Multivariate and correlation analysis of the spectra of polar and lipophilic brain and liver extracts from an MDA-MB-231 cell-derived mouse model revealed a stronger impact of Pd₂Spm on brain metabolome, compared to cDDP. This was expressed by chan

SUBMITTER: Carneiro TJ 

PROVIDER: S-EPMC9693583 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature