Within-family influences on dimensional neurobehavioral traits in a high-risk genetic model.

ABSTRACT:

Background

Genotype-first and within-family studies can elucidate factors that contribute to psychiatric illness. Combining these approaches, we investigated the patterns of influence of parental scores, a high-impact variant, and schizophrenia on dimensional neurobehavioral phenotypes implicated in major psychiatric disorders.

Methods

We quantitatively assessed cognitive (FSIQ, VIQ, PIQ), social, and motor functioning in 82 adult individuals with a de novo 22q11.2 deletion (22 with schizophrenia), and 148 of their unaffected parents. We calculated within-family correlations and effect sizes of the 22q11.2 deletion and schizophrenia, and used linear regressions to assess contributions to neurobehavioral measures.

Results

Proband-parent intra-class correlations (ICC) w

SUBMITTER: Fiksinski AM 

PROVIDER: S-EPMC9693655 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature