The influence of comorbid depression and overweight status on peripheral inflammation and cortisol levels.

ABSTRACT:

Background

Depression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent to which depressive symptoms and overweight status contributed to increased inflammation and abnormal cortisol levels.

Methods

Participants were recruited through the Wellcome Trust NIMA Consortium. The sample of 216 participants consisted of 69 overweight patients with depression; 35 overweight controls; 55 normal-weight patients with depression and 57 normal-weight controls. Peripheral inflammation was measured as high-sensitivity C-Reactive Protein (hsCRP) in serum. Salivary cortisol was collected at multiple points throughout the day to measure cortisol awakening response and diurnal cortisol levels.

Results

Overweight patients with

SUBMITTER: McLaughlin AP 

PROVIDER: S-EPMC9693673 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature