Sex differences in neural correlates of common psychopathological symptoms in early adolescence.

ABSTRACT:

Background

Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interactions are underinvestigated, particularly in adolescence.

Methods

Participants were 14 years of age and part of the IMAGEN study, a large (N = 1526) community-based sample. To test for sex-by-psychopathology interactions in structural grey matter volume (GMV), we used whole-brain, voxel-wise neuroimaging analyses based on robust non-parametric methods. Psychopathological symptom data were derived from the Strengths and Difficulties Questionnaire (SDQ).

Results

We found a sex-by-hyperactivity/inattention interaction in four bra

SUBMITTER: Biondo F 

PROVIDER: S-EPMC9693717 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature