Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans.

ABSTRACT:

Context

Diabetes is an age-related disease; however, the mechanism underlying senescent beta cell failure is still unknown.

Objective

The present study was designed to investigate whether and how the differentiated state was altered in senescent human beta cells by excluding the effects of impaired glucose tolerance.

Methods

We calculated the percentage of hormone-negative/chromogranin A-positive endocrine cells and evaluated the expressions of forkhead box O1 (FoxO1) and Urocortin 3 (UCN3) in islets from 31 nondiabetic individuals, divided into young (<40 years), middle-aged (40-60 years) and elderly (>60 years) groups. We also assessed adaptive unfolded protein response markers glucose-regulated protein 94 (GRP94), and spliced X-box binding protein 1 (XBP1s) in sene

SUBMITTER: Song J 

PROVIDER: S-EPMC9693768 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature