Association of Systemic Trimethyllysine With Heart Failure With Preserved Ejection Fraction and Cardiovascular Events.

ABSTRACT:

Context

Carnitine has been associated with cardiac energy metabolism and heart failure, but the association between its precursors-trimethyllysine (TML) and γ-butyrobetaine (GBB)-and heart failure with preserved ejection fraction (HFpEF) remains unclear.

Objective

To evaluate the relationship between TML-related metabolites and HFpEF in an Asian population.

Methods

The cross-sectional component of this study examined the association between plasma TML-related metabolites and HFpEF, while a prospective cohort design was applied to examine the association with incident cardiovascular events in HFpEF. Included in the study were 1000 individuals who did not have heart failure (non-HF) and 1413 patients with HFpEF. Liquid chromatography mass spectrometry was used to assess

SUBMITTER: Wei H 

PROVIDER: S-EPMC9693784 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature