Maternal use of methamphetamine induces sex-dependent changes in myocardial gene expression in adult offspring.

ABSTRACT: Methamphetamine is a commonly abused illicit stimulant that has prevalent use among women of child-bearing age. While there are extensive studies on the neurological effects of prenatal methamphetamine exposure, relatively little is known about the effect of prenatal methamphetamine on the adult cardiovascular system. Earlier work demonstrated that prenatal methamphetamine exposure sex dependently (females only) sensitizes the adult heart to ischemic injury. These data suggest that prenatal exposure to methamphetamine may induce sex-dependent changes in cardiac gene expression that persist in adult offspring. The goal of this study was to test the hypothesis that prenatal methamphetamine exposure induces changes in cardiac gene expression that persist in the adult heart. Hearts of prenatal

SUBMITTER: Dague A 

PROVIDER: S-EPMC9693808 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature