Pulmonary Fibrosis Induced by CdSe Nanorods and the Therapy with Modified Procyanidinere.

ABSTRACT: The CdSe nanorod as a one-dimensional nanostructure has an excellent performance in many fields, such as healthcare, new energy, and environmental protection. Thus, it is crucial to investigate its potential adverse health effects prior to their wide exposure. The lung tissue would be the main target organ after CdSe nanorods enter living systems. Here, we showed that pulmonary instillation of CdSe nanorods could decrease the vitality of T-SOD and T-AOC in lung tissues of a rat, increase MDA and hydroxyproline levels and lipid peroxidation products, induce mitochondrial cristae breakage and vacuolization, cause inflammatory responses, and finally induce pulmonary fibrosis. The oral administration of modified procyanidinere could significantly increase the content of antioxidant enzymes, sc

SUBMITTER: Yue Z 

PROVIDER: S-EPMC9693992 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature