Pan-cancer analyses reveal the immunotherapeutic value of klotho.

ABSTRACT: Klotho (KL) was initially thought to be a typical "ageing suppressor" gene, but recent studies have suggested that KL is involved in the progression of several types of human cancer. This study aims to analyse whether the expression level of KL could impact patient prognosis, clinical parameters, and tumour immunity in different tumour patients. KL activity was utilized to determine differences between the KL transcript and KL protein. Expression levels were detected by single-sample gene enrichment analysis (GSEA). To explore the inherent mechanisms of KL in tumour immunotherapy, we investigated the possible impact of KL on the tumour microenvironment, immune processes and immune components. GO and KEGG analysis showed that KL was significantly involved in immune response, Inflammation, a

SUBMITTER: Liang J 

PROVIDER: S-EPMC9694098 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature