Influence of Roll Speed during Roll Compaction and Its Effect on the Prediction of Ribbon Solid Fraction.

ABSTRACT: Influence of the roll speed (RS) during roll compaction on ribbon, granule, tablet properties and its effect on the prediction of the ribbon solid fraction at-gap is often neglected or controversially discussed. The aim of this study was to investigate the effect of the RS systematically. Microcrystalline cellulose (MCC) and lactose were compressed at several maximum roll pressures (P_max) and RS combinations using a gap-controlled roll compactor. The ribbon solid fraction after elastic recovery (SF_ribbon), granule size distribution and tabletability of the granules as well as the ribbon solid fraction at-gap (SF_gap) were measured. The Midoux number (Mi), derived from the Johanson model, was used to pre

SUBMITTER: Luck M 

PROVIDER: S-EPMC9694291 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature