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Echinocystic Acid Bidesmoside Saponins from Microglossa afzelii O. Hoffm and Their Cytotoxic Activity against the CAL-27 Oral Squamous Carcinoma Cell Line.

ABSTRACT: This paper describes eight new triterpenoid saponins, including afzeliioside A (1), four acetylated afzeliiosides as pairs of inseparable regioisomers, called afzeliiosides B/C (2/3) and D/E (4/5), afzeliiosides F-H (6-8), and a known impatiprin C (9), which were isolated from the n-BuOH fraction of the liana of Microglossa afzelii. Their structures were established mainly by extensive spectroscopic analysis, including 1D and 2D NMR, HRFAB-MS, tandem ESI-MS/MS, and chemical methods, as well as a comparison of their spectral data with those of related compounds. All the isolates were screened for their cytotoxic activity against the CAL-27 oral squamous carcinoma cell line. Only compounds 4/5 (EC50 = 36.0 μg/mL (32.7 μM)) exhibited moderate cytotoxic activity. This work presents the first chemical and biological investigation of Microglossa afzelii and reports, for the first time, on the isolation of saponins in the genus Microglossa.

SUBMITTER: Tchegnitegni BT 

PROVIDER: S-EPMC9694296 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Echinocystic Acid Bidesmoside Saponins from <i>Microglossa afzelii</i> O. Hoffm and Their Cytotoxic Activity against the CAL-27 Oral Squamous Carcinoma Cell Line.

Tchegnitegni Billy Toussie BT   Ahmed Tehmina T   Ngouafong Francis Tatong FT   Kamso Viviane Flore Kamlo VFK   Teponno Rémy Bertrand RB   Lenta Bruno Ndjakou BN   Tapondjou Léon Azefack LA   Ali Arslan A   Musharraf Syed Ghulam SG  

Metabolites 20221025 11

This paper describes eight new triterpenoid saponins, including afzeliioside A (<b>1</b>), four acetylated afzeliiosides as pairs of inseparable regioisomers, called afzeliiosides B/C (<b>2/3</b>) and D/E (<b>4/5</b>), afzeliiosides F-H (<b>6-8</b>), and a known impatiprin C (<b>9</b>), which were isolated from the <i>n</i>-BuOH fraction of the liana of <i>Microglossa afzelii</i>. Their structures were established mainly by extensive spectroscopic analysis, including 1D and 2D NMR, HRFAB-MS, tan  ...[more]

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