Pharmacogenomics of Cancer Pain Treatment Outcomes in Asian Populations: A Review.

ABSTRACT: In advanced cancer, pain is a poor prognostic factor, significantly impacting patients' quality of life. It has been shown that up to 30% of cancer patients in Southeast Asian countries may receive inadequate analgesia from opioid therapy. This significant under-management of cancer pain is largely due to the inter-individual variability in opioid dosage and relative efficacy of available opioids, leading to unpredictable clinical responses to opioid treatment. Single nucleotide polymorphisms (SNPs) cause the variability in opioid treatment outcomes, yet their association in Asian populations remains unclear. Therefore, this review aimed to evaluate the association of SNPs with variability in opioid treatment responses in Asian populations. A literature search was conducted in Medline and

SUBMITTER: Satkunananthan SE 

PROVIDER: S-EPMC9694298 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature