Recent Advances of Hyaluronan for Skin Delivery: From Structure to Fabrication Strategies and Applications.

ABSTRACT: Hyaluronan (HA) plays a fundamental role in maintaining the homeostasis on skin health. Furthermore, the effect of HA in skin inflammatory diseases is worth studying in the next future. HA and its conjugates change the solubility of active pharmaceutical ingredients, improve emulsion properties, prolong stability, reduce immunogenicity, and provide targeting. HA penetrates to deeper layers of the skin via several mechanisms, which depend on the macromolecular structure and composition of the formulation. The cellular and molecular mechanisms involved in epidermal dysfunction and skin aging are not well understood. Nevertheless, HA is known to selectively activate CD44-mediated keratinocyte signaling that regulates its proliferation, migration, and differentiation. The molecular size of HA

SUBMITTER: Juhascik M 

PROVIDER: S-EPMC9694326 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature