The Future of Targeted Treatment of Primary Sjogren's Syndrome: A Focus on Extra-Glandular Pathology.

ABSTRACT: Primary Sjögren's syndrome (pSS) is a chronic, systemic autoimmune disease defined by exocrine gland hypofunction resulting in dry eyes and dry mouth. Despite increasing interest in biological therapies for pSS, achieving FDA-approval has been challenging due to numerous complications in the trials. The current literature lacks insight into a molecular-target-based approach to the development of biological therapies. This review focuses on novel research in newly defined drug targets and the latest clinical trials for pSS treatment. A literature search was conducted on ClinicalTrials.gov using the search term "Primary Sjögren's syndrome". Articles published in English between 2000 and 2021 were included. Our findings revealed potential targets for pSS treatment in clinical trials and the m

SUBMITTER: Zeng W 

PROVIDER: S-EPMC9694487 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature