Severe Obstructive Sleep Apnea Disrupts Vigilance-State-Dependent Metabolism.

ABSTRACT: The direct pathophysiological effects of obstructive sleep apnea (OSA) have been well described. However, the systemic and metabolic consequences of OSA are less well understood. The aim of this secondary analysis was to translate recent findings in healthy subjects on vigilance-state-dependent metabolism into the context of OSA patients and answer the question of how symptomatic OSA influences metabolism and whether these changes might explain metabolic and cardiovascular consequences of OSA. Patients with suspected OSA were assigned according to their oxygen desaturation index (ODI) and Epworth Sleepiness Scale (ESS) score into symptomatic OSA and controls. Vigilance-state-dependent breath metabolites assessed by high-resolution mass spectrometry were used to test for a difference in bot

SUBMITTER: Schmidt F 

PROVIDER: S-EPMC9694615 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature