Polygenic Risk Score and Risk Factors for Preeclampsia and Gestational Hypertension.

ABSTRACT: Preeclampsia and gestational hypertensive disorders (GHD) are common complications of pregnancy that adversely affect maternal and offspring health, often with long-term consequences. High BMI, advanced age, and pre-existing conditions are known risk factors for GHD. Yet, assessing a woman's risk of GHD based on only these characteristics needs to be reevaluated in order to identify at-risk women, facilitate early diagnosis, and implement lifestyle recommendations. This study demonstrates that a risk score developed with machine learning from the case-control genetics dataset can be used as an early screening test for GHD. We further confirm BMI as a risk factor for GHD and investigate a relationship between GHD and genetically constructed anthropometric measures and biomarkers. Our result

SUBMITTER: Perisic MM 

PROVIDER: S-EPMC9694636 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature