In Silico Characterization of African Swine Fever Virus Nucleoprotein p10 Interaction with DNA.

ABSTRACT: African swine fever virus (ASFV) is the etiological agent of a highly contagious, hemorrhagic infectious swine disease, with a tremendous sanitary and economic impact on a global scale. Currently, there are no globally available vaccines or treatments. The p10 protein, a structural nucleoprotein encoded by ASFV, has been previously described as capable of binding double-stranded DNA (dsDNA), which may have implications for viral replication. However, the molecular mechanism that governs this interaction is still unknown, mostly due to the lack of a structural model for this protein. In this work, we have generated an ab initio model of the p10 protein and performed extensive structural characterization, using molecular dynamics simulations to identify the motifs and residues regulating DNA

SUBMITTER: Istrate C 

PROVIDER: S-EPMC9694697 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature