dNAGLU Extends Life Span and Promotes Fitness and Stress Resistance in Drosophila.

ABSTRACT: To identify new factors that promote longevity and healthy aging, we studied Drosophila CG13397, an ortholog of the human NAGLU gene, a lysosomal enzyme overexpressed in centenarians. We found that the overexpression of CG13397 (dNAGLU) ubiquitously, or tissue specifically, in the nervous system or fat body could extend fly life span. It also extended the life span of flies overexpressing human Aβ42, in a Drosophila Alzheimer's disease (AD) model. To investigate whether dNAGLU could influence health span, we analyzed the effect of its overexpression on AD flies and found that it improved the climbing ability and stress resistance, including desiccation and hunger, suggesting that dNAGLU improved fly health span. We found that the deposition

SUBMITTER: Xue R 

PROVIDER: S-EPMC9694703 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature