Effect of the Silica-Magnetite Nanocomposite Coating Functionalization on the Doxorubicin Sorption/Desorption.

ABSTRACT: A series of new composite materials based on Fe₃O₄ magnetic nanoparticles coated with SiO₂ (or aminated SiO₂) were synthesized. It has been shown that the use of N-(phosphonomethyl)iminodiacetic acid (PMIDA) to stabilize nanoparticles before silanization ensures the increased content of a SiO₂ phase in the Fe₃O₄@SiO₂ nanocomposites (NCs) in comparison with materials obtained under similar conditions, but without PMIDA. It has been demonstrated for the first time that the presence of PMIDA on the surface of NCs increases the level of Dox loading due to specific binding, while surface modification with 3-aminopropylsilane, on the contrary, significantly reduces the sorption capacity of materials. T

SUBMITTER: Demin AM 

PROVIDER: S-EPMC9694706 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature