Interactions among maternal smoking, breastfeeding, and offspring genetic factors on the risk of adult-onset hypertension.

ABSTRACT:

Background

Previous studies have reported that maternal smoking during pregnancy and breastfeeding may affect the occurrence of hypertension, but whether early life factors modify the impact of the offspring's genetic risk on hypertension is still unknown. The aim of this study was to investigate the relationships among maternal smoking and breastfeeding with adult-onset hypertension and the modified impact of offspring genetic susceptibility.

Methods

This study included 437,185 participants from the UK Biobank who were initially free of hypertension and provided a prospective cohort of individuals aged 40 to 69 years. The association of maternal smoking during pregnancy and breastfeeding with hypertension was examined by using the Cox regression model. Then, a polygenic ris

SUBMITTER: Liang J 

PROVIDER: S-EPMC9694874 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature