Health effects of milk consumption: phenome-wide Mendelian randomization study.

ABSTRACT:

Background

We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the health effects of milk consumption in the European population.

Methods

Rs4988235 located upstream of the LCT gene was used as the instrumental variable for milk consumption. MR-PheWAS analysis was conducted to map the association of genetically predicted milk consumption with 1081 phenotypes in the UK Biobank study (n=339,197). The associations identified in MR-PheWAS were examined by two-sample MR analysis using data from the FinnGen study (n=260,405) and international consortia. A systematic review of MR studies on milk consumption was further performed.

Results

PheWAS and two-sample MR analyses found robust ev

SUBMITTER: Yuan S 

PROVIDER: S-EPMC9694907 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature