Design of 4-Substituted Sulfonamidobenzoic Acid Derivatives Targeting Coxsackievirus B3.

ABSTRACT: A series of novel 4-substituted sulfonamidobenzoic acid derivatives was synthesized as the structural evolution of 4-(4-(1,3-dioxoisoindolin-2-yl)phenylsulfonamido)benzoic acid, which is the known inhibitor of the enterovirus life cycle. Antiviral properties of prepared compounds were evaluated in vitro using phenotypic screening and viral yield reduction assay. Their capsid binding properties were verified in thermostability assay. We identified two new hit-compounds (4 and 7a) with high activity against the coxsackievirus B3 (Nancy, CVB3) strain with potencies (IC₅₀ values of 4.29 and 4.22 μM, respectively) which are slightly superior to the reference compound 2a (IC₅₀ 5.54 μM). Both hits changed the heat inactivation of CVB3 in vitro<

SUBMITTER: Shetnev AA 

PROVIDER: S-EPMC9694965 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature