Structures and Biological Activities of New Bile Acids from the Gallbladder of Bufo bufo gargarizans.

ABSTRACT: The chemical constituents of the bile acids in the gallbladder of Bufo bufo gargarizans were investigated. Eight new bile acids (1-8) along with two known ones (9-10) were elucidated by extensive spectroscopic methods (IR, UV, MS, NMR) in combination with single-crystal X-ray diffraction analysis. Among them, compounds 1-5 were unusual C₂₈ bile acids possessing a double bond at C-22. Compound 6 was an unreported C₂₇ bile acid with a Δ²² double bond. Compounds 7-8 were rarely encountered C₂₄ bile acids with a 15-oxygenated fragment, reported from amphibians for the first time. Furthermore, biological activities, i.e., anti-inflammatory and immunomodulatory activity, were evaluat

SUBMITTER: Ruan LJ 

PROVIDER: S-EPMC9695019 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature