Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease.

ABSTRACT: Emerging studies indicate that the Hippo pathway, a highly conserved pathway that regulates organ size control, plays an important role in governing ovarian physiology, fertility, and pathology. Specific to the ovary, the spatiotemporal expression of the major components of the Hippo signaling cascade are observed throughout the reproductive lifespan. Observations from multiple species begin to elucidate the functional diversity and molecular mechanisms of Hippo signaling in the ovary in addition to the identification of interactions with other signaling pathways and responses to various external stimuli. Hippo pathway components play important roles in follicle growth and activation, as well as steroidogenesis, by regulating several key biological processes through mechanisms of cell prol

SUBMITTER: Clark KL 

PROVIDER: S-EPMC9695108 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature