Characterization of Retinal Development in 13-Lined Ground Squirrels.

ABSTRACT:

Purpose

The cone-dominant, 13-lined ground squirrel (13-LGS) retina mimics the human central retina, but a thorough examination of retinal development in this species has not been reported. Here, the embryonic and postnatal development of the 13-LGS retina was studied to further characterize 13-LGS as a practical alternative animal model for investigating cone-based vision in health and disease.

Methods

The spatiotemporal expression of key progenitor and cell type markers was examined in retinas from defined embryonic and postnatal stages using immunohistochemistry. Postnatal gene expression changes were validated by quantitative PCR.

Results

The 13-LGS neuroblastic layer expressed key progenitor markers (Sox2, Vsx2, Pax6, and Lhx2) at E18. Sequential cell fate determ

SUBMITTER: Kandoi S 

PROVIDER: S-EPMC9695149 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature