Epitranscriptome: Review of Top 25 Most-Studied RNA Modifications.

ABSTRACT: The alphabet of building blocks for RNA molecules is much larger than the standard four nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of these nucleotides into distinct chemical entities that are structurally and functionally different from their unmodified counterparts. Some of these modifications are constituent and critical for RNA functions, while others serve as dynamic markings to regulate the fate of specific RNA molecules. Together, these modifications form the epitranscriptome, an essential layer of cellular biochemistry. As of the time of writing this review, more than 300 distinct RNA modifications from all three life domains have been identified. However, only a few of the most well-established modifications are included in most rev

SUBMITTER: Arzumanian VA 

PROVIDER: S-EPMC9695239 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature