Antibody-Based Immunotherapies as a Tool for Tackling Multidrug-Resistant Bacterial Infections.

ABSTRACT: The discovery of antimicrobials is an outstanding achievement of mankind that led to the development of modern medicine. However, increasing antimicrobial resistance observed worldwide is rendering commercially available antimicrobials ineffective. This problem results from the bacterial ability to adapt to selective pressure, leading to the development or acquisition of multiple types of resistance mechanisms that can severely affect the efficacy of antimicrobials. The misuse, over-prescription, and poor treatment adherence by patients are factors strongly aggravating this issue, with an epidemic of infections untreatable by first-line therapies occurring over decades. Alternatives are required to tackle this problem, and immunotherapies are emerging as pathogen-specific and nonresistance

SUBMITTER: Seixas AMM 

PROVIDER: S-EPMC9695245 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature