Clinical and Virological Characteristics and Prognostic Factors in Viral Necrotizing Retinitis.

ABSTRACT:

Purpose

Describe the clinical and virological characteristics of viral necrotizing retinitis (VNR) and assess its prognostic factors.

Methods

Retrospective study (Pitié Salpêtrière Hospital, Paris) of consecutive VNR patients diagnosed and monitored by qPCR on aqueous humor between 2015 and 2019. All patients received induction therapy with intravenous +/- intravitreal injections (IVI) of antivirals.

Results

Forty-one eyes of 37 patients with a mean age of 56 years were included. Involved viruses were VZV (44%), CMV (37%) and HSV2 (19%). Acute retinal necrosis represented 51%, progressive outer retinal necrosis 12% and CMV retinitis 37% of eyes. Forty-six percent of patients were immunocompromised. Median BCVA was 0.7 LogMAR at baseline and 0.8 LogMAR after an average

SUBMITTER: Fitoussi L 

PROVIDER: S-EPMC9695359 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature