Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis.

ABSTRACT:

Background

Optical coherence tomography angiography (OCT-A) is a novel technique allowing non-invasive assessment of the retinal vasculature. During relapsing remitting multiple sclerosis (RRMS), retinal vessel loss occurs in eyes suffering from acute optic neuritis and recent data suggest that retinal vessel loss might also be evident in non-affected eyes. We investigated whether alterations of the retinal vasculature are linked to the intrathecal immunity and whether they allow prognostication of the future disease course.

Material and methods

This study includes two different patient cohorts recruited at a tertiary German academic multiple sclerosis center between 2018 and 2020 and a cohort of 40 healthy controls. A total of 90 patients with RRMS undergoing lumbar punctur

SUBMITTER: Noll C 

PROVIDER: S-EPMC9695398 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature