Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and H₂S Donors.

ABSTRACT: Glaucoma is a group of eye diseases consisting of optic nerve damage with corresponding loss of field vision and blindness. Hydrogen sulfide (H₂S) is a gaseous neurotransmitter implicated in various pathophysiological processes. It is involved in the pathological mechanism of glaucomatous neuropathy and exerts promising effects in the treatment of this disease. In this work, we designed and synthetized new molecular hybrids between antiglaucoma drugs and H₂S donors to combine the pharmacological effect of both moieties, providing a heightened therapy. Brinzolamide, betaxolol and brimonidine were linked to different H₂S donors. The H₂S-releasing properties of the new compounds were evaluated in a phosphate buffer solution by the amperometric appro

SUBMITTER: Sparaco R 

PROVIDER: S-EPMC9695456 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature