Photobiomodulation and visual stimulation against cognitive decline and Alzheimer's disease pathology: A systematic review.

ABSTRACT:

Introduction

Given the ineffectiveness of the available drug treatment against Alzheimer disease (AD), light-based therapeutic modalities have been increasingly receiving attention with photobiomodulation (PBM) and, more recently, visual stimulation (VS) being among the most promising approaches. However, the PBM and VS light parameters tested so far, as well as their outcomes, vary a lot with conflicting results being reported.

Methods

Based on Scopus, PubMed, and Web of Science databases search, this systematic review summarizes, compares, and discusses 43 cell, animal, and human studies of PBM and VS related to cognitive decline and AD pathology.

Results

Preclinical work suggests that PBM with 640±30-nm light and VS at 40 Hz attenuates Aβ and Tau pathology and impr

SUBMITTER: Monteiro F 

PROVIDER: S-EPMC9695760 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature