Ochratoxin A Defective Aspergillus carbonarius Mutants as Potential Biocontrol Agents.

ABSTRACT: Aspergillus carbonarius is one of the main species responsible for wine, coffee and cocoa toxin contamination. The main mycotoxin produced by this fungus, ochratoxin A (OTA), is a secondary metabolite categorized as a possible carcinogen because of its significant nephrotoxicity and immunosuppressive effects. A polyketide synthase gene (otaA) encodes the first enzyme in the OTA biosynthetic pathway. It is known that the filamentous fungi, growth, development and production of secondary metabolites are interconnected processes governed by global regulatory factors whose encoding genes are generally located outside the gene clusters involved in the biosynthesis of each secondary metabolite, such as the veA gene, which forms part of the VELVET complex. Different fungal st

SUBMITTER: Llobregat B 

PROVIDER: S-EPMC9695793 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature