Dose Titration of Solid Dosage Forms via FDM 3D-Printed Mini-Tablets.

ABSTRACT: The robustness of 3D-printed mini-tablets as a platform to administer milligram dosages, intended for age-specific therapy, without the need of tablet splitting while maintaining similar release profiles, was investigated. Griseofulvin, as a model poorly water-soluble drug, and hydroxypropyl cellulose along with Kollicoat Protect as polymers were used to prepare filaments at 1-20% drug concentrations via hot-melt extrusion (HME). Higher drug concentrations served for testing the feasibility of a reduced number of mini-tablets to be administered. A reliable dose titration in the range 0.19-3.91 mg at a high accuracy (R² of 0.999) was achieved through composite unit (multi-unit) mini-tablets. All mini-tablets produced had excellent content uniformity and their label claim values w

SUBMITTER: Gorkem Buyukgoz G 

PROVIDER: S-EPMC9695869 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature