A Pan-Cancer Atlas of Differentially Interacting Hallmarks of Cancer Proteins.

ABSTRACT: Cancer hallmark genes and proteins orchestrate and drive carcinogenesis to a large extent, therefore, it is important to study these features in different cancer types to understand the process of tumorigenesis and discover measurable indicators. We performed a pan-cancer analysis to map differentially interacting hallmarks of cancer proteins (DIHCP). The TCGA transcriptome data associated with 12 common cancers were analyzed and the differential interactome algorithm was applied to determine DIHCPs and DIHCP-centric modules (i.e., DIHCPs and their interacting partners) that exhibit significant changes in their interaction patterns between the tumor and control phenotypes. The diagnostic and prognostic capabilities of the identified modules were assessed to determine the ability of the mod

SUBMITTER: Kori M 

PROVIDER: S-EPMC9695992 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature