Air Pollution and Maximum Temperature Are Associated with Neurodevelopmental Regressive Events in Autism Spectrum Disorder.

ABSTRACT: Neurodevelopmental regression (NDR) is an enigmatic event associated with autism spectrum disorder (ASD) during which a child loses previously acquired skills and develops ASD symptoms. In some, a trigger which precedes the NDR event, such as a fever, can be identified, but in many cases no trigger is obvious. We hypothesize that air pollution (PM_2.5) may trigger NDR, especially in those children without an identified trigger. Average daily PM_2.5, ozone, precipitation and maximum temperature (T_max) were derived from Environmental Protection Agency models and National Oceanic and Atmospheric Administration monitors based on zip-code information from 83 ASD participants during the six-weeks following the onset month of an NDR event and a reference period defi

SUBMITTER: Frye RE 

PROVIDER: S-EPMC9696106 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature